A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI)
Objective. To evaluate the efficacy of KSI-101 compared to sham.
Clinical Trials
Our Ophthalmic Studies
The clinician-scientists at Cascade Medical Research Institute (CMRI) lead ophthalmic studies that bring tomorrow's promise of better vision and outcomes to patients today.
Randomized Trial Comparing Immediate Versus Deferred Surgery for Symptomatic Epiretinal Membranes
Objective. Compare visual acuity outcomes at 36 months between eyes randomized to immediate versus deferred surgery.
Corneal Collagen Cross-Linking in Eyes With Corneal Thinning
Objective. To determine the safety and effectiveness of PXL Platinum 330 in treating corneal thinning conditions.
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy (GA)
Objective. To evaluate the effect of systemic C5 inhibition on GA lesion growth over 52 weeks.
GALLOP
A phase 2, randomized, placebo-controlled, multicenter, masked study to evaluate the efficacy, safety, tolerability, and pharmacodynamics of multidose apl-3007 in combination with syfovre/pegcetacoplan (apl-2) in patients diagnosed with geographic atrophy secondary to age-related macular degeneration
Objective. To evaluate the efficacy of multidose APL-3007 and Syfovre/pegcetacoplan (APL-2) compared to Syfovre alone
TORRONTES
A randomized double-masked, multicenter, 3-arm, pivotal Phase 2/3 study to evaluate the efficacy and safety of intravitreal (IVT) EYE201/MK-8748 compared to aflibercept (2 mg) in participants with neovascular age-related macular degeneration (NVAMD)
Objective. To evaluate the efficacy and safety of intravitreal (IVT) EYE201/MK-8748 compared to aflibercept.
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A 2-Year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD
Objective. To compare the efficacy of EYP-1901 against aflibercept.
A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer and Tabirafusp Tedromer Compared to Aflibercept in Participants With Neovascular (Wet) Age-Related Macular Degeneration (wAMD)
Objective. To evaluate the efficacy of tarcocimab-ted 5 mg compared to aflibercept 2 mg.
APEX
An Open Label, Multicenter Platform Study on the Safety, Tolerability, Bioactivity, and Pharmacokinetics of Multiple Intravitreal Therapies in Retinal Diseases (DME / MESI)
Objective. To evaluate the ocular and systemic safety and tolerability of intravitreal KSI-101.
A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of ANX007 in Participants With Geographic Atrophy (GA)
Objective. To evaluate efficacy of intravitreal (IVT) injections of ANX007.
A Randomized, Double-Masked, Multi-Center, 3-Arm Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal EYE103 Compared With Intravitreal Ranibizumab (0.5mg) in Participants With Diabetic Macular Edema (DME)
Objective. To demonstrate that EYE103 (0.5 mg or 0.8 mg) is non-inferior to ranibizumab 0.5 mg.
Evaluation of K8 in Subjects With Geographic Atrophy (GA)
Objective. This study will determine safety and efficacy of intravitreal injections of K8 in subjects with advanced non-exudative AMD.
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A study to evaluate the efficacy, durability, and safety of KSI-301 vs. aflibercept in patients with macular edema due to retinal vein occlusion (RVO).
A study of NGM in participants with geographic atrophy.
A Phase 3 study of intravitreal OPT-302 in combination with aflibercept, compared with aflibercept alone, in participants with neovascular age-related macular degeneration (AMD).
A Phase III, multicenter, randomized, double-masked, active comparator-controlled study to evaluate the efficacy and safety of faricimab in patients with macular edema secondary to central retinal or hemiretinal vein occlusion (CRVO / HRVO).
A study to evaluate the efficacy and safety of brolucizumab vs. panretinal photocoagulation laser in patients with proliferative diabetic retinopathy (PDR).
A prospective, randomized, double-masked, active comparator-controlled, multi-center, two-arm, Phase 3 study to evaluate the efficacy and safety of intravitreal KSI-301 compared with intravitreal aflibercept in participants with neovascular (wet) age-related macular degeneration (wAMD).
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